Associate Professional Specialist fpr Connectomics Research
Princeton University for Neuroscience Institute
United States

Understanding behavior at all levels of function, from systems to cells, is one of the great challenges of modern biology. The Princeton Neuroscience Institute focuses on understanding principles of function and interaction that apply across brain regions. Towards that goal, PNI develops and applies advanced microscopy imaging techniques for measuring neural circuit dynamics in the functioning brain. PNI hosts world leading researchers that explore the ways in which the brain acquires, modifies and stores information during cognitive processes, such as learning, memory and decision making. PNI places particular emphasis on the close connection between theory, modeling, and experimentation by studying brain function on a circuit level.

The Princeton Neuroscience Institute is seeking an Associate or more senior Professional Specialist to lead the new high-throughput volume Electron Microscopy facility for connectomics research. The volume Electron Microscopy facility comprises several scanning and transmission Electron Microscopes and multiple automated tape collecting ultramicrotomes. The volume Electron Microscopy facility is an integrated part of a large, collaborative effort at PNI to combine in vivo behavioral assays with functional imaging and ultrastructural reconstruction of the underlying neuronal substrates in various brain regions.

The successful candidate will be responsible for the large-scale volume EM data acquisition, the operation and maintenance of the Microscopes and the related instruments. The candidate will conceptualize, organize and undertake EM sample preparation and visualization and will provide training on sample preparation and the operation of the electron microscopes to PNI scientists, faculty and staff.

Essential Qualifications:
*PhD degree in Neuroscience, Physics, Electrical Engineering or other related field
*Outstanding track-record of hands-on Electron Microscopy experience
*Excellent communication skills, ability to organize, manage and maintain an Electron Microscopy facility with multiple users and several custom high-throughput Transmission Electron Microscopes and Scanning Electron Microscopes.
*Ability to work collaboratively in a team as well as independently on a wide variety of research projects.
*At least three to five years hands-on experience in an Electron Microscopy laboratory covering sample preparation, operating and maintenance of microscope and identification of ultra-structural features of normal and abnormal biological tissue.
*Must be detail-oriented, focused, and highly motivated. A strong background in image analysis a plus.

Preferred Qualifications:
*electron microscopy, light microscopy
*histological labeling techniques, viral labeling, immunolabeling
*stereotaxic surgery
*image analysis software and systems (e.g. FIJI/ImageJ, EyeWire)

Interested applicants must apply at and include a cover letter, curriculum vitae, and contact information for two references.

This position is subject to the University's background check policy.

Requisition No: D-18-PNI-00009

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