Employment1.0 FTE
Gross monthly salary€ 2,770 - € 3,539
Required backgroundResearch University Degree
Organizational unitFaculty of Science
Application deadline30 September 2023
The focus of our lab is to improve our understanding of biological mechanisms underpinning psychiatric and cognitive aspects in rare genetic syndromes, such as the Witteveen-Kolk syndrome, to be able to design tailored intervention strategies targeted at the severe behaviour and psychiatric problems that are frequently encountered. Using state-of-the-art functional assays such as iPSCs, brain organoids, assembloids and in utero-electroporation, we are investigating the role of neurodevelopmental disorder-causing genes in corticogenesis.
As a PhD candidate you will work on the assessment of gene expression changes in specific cell populations and cell biological characterisation and analyses of the organoids, including 2D cryosection immunofluorescence microscopy, deconvolution and morphometrics. You will further have the opportunity to use a broad spectrum of methods and techniques including mouse genetics, functional and behavioural assays, immunohistochemistry, fluorescence microscopy (wide-field, confocal and light sheet), cell and molecular biology and biochemistry. Lastly, you will be expected to supervise Master's students. Profile
We areThe Kolk lab (Developmental Neurobiology) is part of the Donders Centre for Neuroscience (DCN), which is one of the six research institutes of the Faculty of Science at Radboud University (Nijmegen, Netherlands). The main aim of DCN is to understand the complex neural networks underlying perceptual, motor and cognitive brain functions. We study these networks by employing experimental as well as computational approaches.DCN is part of the world-renowned Donders Institute for Brain, Cognition and Behaviour, a world-class interfaculty neuroscience institute with a lively and interactive culture housing more than 800 researchers devoted to understanding the mechanistic underpinnings of the human mind. Research at the Donders Institute is focused around four themes:
Excellent, state-of-the-art research facilities are available for the broad range of neuroscience research that is being conducted at the Donders Institute. The Donders Institute has been assessed by an international evaluation committee as 'excellent' and recognised as a 'very stimulating environment for top researchers, as well as for young talent'. The Donders Institute fosters a collaborative, multidisciplinary, supportive research environment with a diverse international staff. English is the lingua franca at the Institute.
We are keen to meet critical thinkers who want to look closer at what really matters. People who, from their expertise, wish to contribute to a healthy, free world with equal opportunities for all. This ambition unites more than 24,000 students and 5,600 employees at Radboud University and requires even more talent, collaboration and lifelong learning. You have a part to play! |