PhD Student in Neuroscience Grenoble Institute of Neurosciences

Our group focuses on direct lineage reprogramming or cell-fate conversion toward the neuronal lineage as a novel cell-based therapy for several neurological disorders. Several reports showed that glial cells can be efficiently converted into functional neurons as a new avenue for brain repair (Heinrich et al., PLoS Biology, 2010; Heinrich et al., Nature Protoc, 2011; Karow et al., Cell Stem Cell, 2012; Heinrich et al., Stem Cell Reports, 2014; Heinrich et al., Nature Cell Biology, 2015). One of the next challenges is to reprogram non-neuronal cells within the injured brain into functional neurons that acquire a given phenotype, integrate into endogenous circuits and modulate the activity of these networks with beneficial effects. The main objective of our group is to convert glial cells from the epileptic brain into clinically relevant neurons. 
In parallel, our group also studies the physiopathological mechanisms and the remodeling of neuronal networks responsible for seizure development, with a particular emphasis on Mesio-Temporal Lobe Epilepsy, the most common form of intractable epilepsies. 
We are looking for a highly motivated scientist holding a Master in Biology (or equivalent) and willing to join a challenging research area at the edge of cellular biology and neurosciences. The candidate will have a background in neurosciences and/or cellular biology, and should have technical experience in cell biology, biochemistry as well as cellular and molecular biology. Previous experience in working with living mice and/or electrophysiology (including patch-clamp and/or field recordings in brain slices) would be helpful. 
While knowledge of the French language is not required, English proficiency is mandatory and strong communication skills are expected. Please send your CV (including experience and two academic references) and a cover letter describing your motivations and research interests to Christophe Heinrich.