Research Associate in Clinical Neurosciences
University of Cambridge Department of Clinical Neurosciences
United Kingdom

The University of Cambridge wishes to appoint a postdoctoral scientist to join the research group of Dr Jelle van den Ameele at the Department of Clinical Neurosciences and the MRC Mitochondrial Biology Unit

The position is part of a Wellcome-funded project to identify novel determinants of tissue-specific phenotypes of mitochondrial and neurodegenerative diseases. The focus of your project will be on neural stem cell-niche interactions and intercellular exchange of metabolites in the context of mitochondrial dysfunction. Most of the work involves Drosophila genetics, various cutting-edge molecular biology and sequencing techniques, microdissection, and confocal and super-resolution imaging in live and fixed samples. You will have the opportunity to apply findings from Drosophila to other model systems. You will drive the project within the laboratory, together with the group leader and assist in supervision of junior lab members. You will be encouraged to apply for external funding and receive support to undertake further training and career development.

Candidates are expected to be independent, highly motivated, and keen to work collaboratively with internal and external scientists. You will join a young and dynamic group, and demonstrate core values of the lab, which include enthusiasm, openness and integrity. A PhD in molecular biology, biochemistry, genetics or a related field is required. You will have a publication track record, with a good, peer-reviewed first author paper, either published or in press. Ideal qualifications include experience with Drosophila genetics, mitochondrial metabolism and neural stem cell or glial biology, but others are welcome to apply.

The position offers a competitive salary and enjoys the diverse and highly interactive research environment of the world-renowned Mitochondrial Biology Unit and Department of Clinical Neurosciences at the Cambridge Biomedical Campus.

Key responsibilities:

  • Undertake cutting edge research aimed at key questions related to mitochondrial dysfunction and the neural stem cell niche in Drosophila. Stay up to date with relevant scientific literature.
  • Drive the project within the laboratory, work closely together with the group leader, while also demonstrating creativity and initiative to develop novel approaches and research questions.
  • Contribute to the smooth running of the research group and wider institute, assist in supervision and support of junior lab members, communicate openly about results.
  • Be open to opportunities to learn novel techniques and to apply findings from Drosophila to other model systems.
  • Contribute to the dissemination of results by preparing results for publication, writing papers and reports, and by presenting results at conferences and seminars.
  • Identify opportunities for additional funding, apply for external grants when appropriate.

Essential criteria:

  • A PhD in molecular biology, biochemistry, genetics or a related field
  • Independent, highly motivated individual, who is keen to work collaboratively with internal and external scientists
  • Demonstrate core values of enthusiasm, openness and integrity.
  • Publication track record, with a good, peer-reviewed first author paper, either published or in press

Desirable criteria:

  • Experience with Drosophila genetics and insight in the utility of model organisms to study human disease.
  • In-depth knowledge of mitochondrial or cellular metabolism
  • Experience with neural stem cell and glial biology, preferably but not necessarily in Drosophila.
  • Experience with confocal and super-resolution microscopy, live imaging and use of FRET-based sensors.
  • Experience with basic molecular cloning techniques
  • Experience with next-generation sequencing library preparation
  • Experience with bio-informatic analysis, in particular ChIP-seq/DamID-seq, and bulk or single-cell RNAseq.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 2nd July 2020.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference ZE23202 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


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